Analisis In Silico Senyawa Aktif Sprirulina platensis sebagai Inhibitor Tirosinase
In Silico Analysis of Spirulina platensis Active Compounds as Tyrosinase Inhibitor
Hyperpigmentation is a condition when melanin is overproduced, causing spots on the skin. This condition apart from causing aesthetic problems, can also increase the production of reactive oxygen species at the skin. One way to deal with hyperpigmentation is through inhibiting the key enzyme for melanin synthesis which is tyrosinase. Spirulina platensis is a microalgae that has been widely used as a supplement and medicine because of its high nutritional content. S. platensis extract has been proven in vitro to have the ability to inhibit the tyrosinase enzyme. This study aims to find active compounds in S. platensis that have the potential as tyrosinase enzyme inhibitors. The active compounds found in S. platensis were searched through literature studies and then selected based on affinity, toxicity, and Lipinski's Rule. Molecular docking analysis was carried out with selected compounds against the tyrosinase enzyme with kojic acid as the control ligand. The results of molecular docking showed that kaempferol has the best potential as tyrosinase inhibitor because it has the most negative ΔG thus has the best affinity with the tyrosinase enzyme.
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